The Industrial Cobras ran the ball all over the Ingleside Mustangs on their way to a 39-13 victory.
With just over three minutes left in the third quarter, the Ganado Indians trailed the Palacios Sharks, 21-9.
The Edna Cowboys got off to a good start with a strong showing from their defense, but were unable to come away with the win.
The Industrial Cobras fell to Shiner 38-14 to fall to 1-1 on the season.
Ganado and Brazos squared off Friday night for the Indians first home game.