The Edna Cowboys got off to a good start with a strong showing from their defense, but were unable to come away with the win.
The Industrial Cobras fell to Shiner 38-14 to fall to 1-1 on the season.
Ganado and Brazos squared off Friday night for the Indians first home game.
The Edna Cowboys opened the season by travelling to Caldwell. They took care of business and defeated Caldwell 29-16.
With Ethan Guerra leading the way with three rushing touchdowns in the first quarter and a half, the Ganado Indians blew away Lousie with a 71-6 victory.