The Industrial Cobras fell to Shiner 38-14 to fall to 1-1 on the season.
Ganado and Brazos squared off Friday night for the Indians first home game.
The Edna Cowboys opened the season by travelling to Caldwell. They took care of business and defeated Caldwell 29-16.
With Ethan Guerra leading the way with three rushing touchdowns in the first quarter and a half, the Ganado Indians blew away Lousie with a 71-6 victory.
The Ganado minors softball team will began their state tournament play Friday at 8 p.m.